Director's Credentials

Undergraduate:
Bucknell University, Lewisburg, Pennsylvania, June 1979

Medical School:
Jefferson Medical College, Philadelphia, Pennsylvania, June 1983.

Honors:
Phi Beta Kappa, Alpha Omega Alpha, Phi Eta Sigma, Phi Sigma, Hobart Amory Hare Society.

Prize Poster Award, 46th Annual Meeting of American Fertility Society, Washington, D.C., October 17, 1990. Subject: Luteal Phase Support with Human Chorionic Gonadotropin Does Not Improve Fecundity Rate in Human Menopausal Gonadotropin Stimulated Cycles.

Internship:
Rotating Internship, Mercy Hospital, Pittsburgh,
Pennsylvania, 1983-1984.

Residency:
Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, 1984-1988.

Fellowship:
Reproductive Endocrinology and Infertility
Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, Michigan,1988-1990.

Certified, American Board of Obstetrics and Gynecology, December 1991

Certified, Reproductive Endocrinology and Infertility Division of American Board of Obstetrics and Gynecology, December 1992

Recertified, General Obstetrics and Gynecology, and Reproductive Endocrinology and Infertility, February 1999.

Certified, American Board of Bioanalysis High-complexity Clinical Laboratory Director (HCLD), December 1996

American College of Obstetricians and Gynecologists - American Society for Reproductive Medicine

East Tennessee OB/GYN Society (President 1996 & 1997)

Society Development Committee for the American Fertility Society (1990-1994)

Society for the Study of Reproduction

Society of Reproductive Surgeons, April 1994.

Society of Reproductive Endocrinologists

Director, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, University of Tennessee Medical Center, College of Medicine - Knoxville Unit, Knoxville, Tennessee, July 1992-Present.

Associate Professor, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, University of Tennessee Medical Center, Knoxville, Tennessee, 1995-Present.

Assistant Professor, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, University of Tennessee Medical Center, Knoxville, Tennessee, 1990-1994.

Clinical Instructor, Wayne State University School of Medicine, Detroit, Michigan, 1988-1990.

University of Tennessee Medical Center at Knoxville, Active Staff, 1990 - Present.

St. Mary's Medical Center, Knoxville, Tennessee, Courtesy Staff, 1990 - Present.

Ft. Sanders Regional Medical Center, Knoxville, Tennessee, Courtesy Staff, 1990 - Present.

Ft. Sanders Parkwest Medical Center, Knoxville, Tennessee, Courtesy Staff 1994.

Baptist Hospital, Knoxville, Tennessee Courtesy Staff 1994.

Blount Memorial Hospital, Maryville, Tennessee Courtesy Staff 1995.

Church MW, Kaufmann RA, Keenan JA, et al: Effects of Prenatal Cocaine Exposure. In: Biochemistry and Physiology of Substance Abuse, Vol. III. Tuscon: CRC Press, 1991.

Massey PJ, Caudle MR, Keenan JA, and Chen TT: The Roles of the Cytoskeleton in Steroidogenesis: The Actions of Taxol and Other Cytoskeletal Agents. "Taxane Anticancer Agents: Basic Science and Current Status," George G, et al,eds., ACS Books, 1995.

Bukovsky A, Caudle MR, Keenan JA: Regulation of Ovarian Function by Immune System Components: The Tissue Control System (TCS). "Malphigi Volumes On Functional Microanatomy: Microscopy of Reproduction and Development," Pietro M. Motta, M.D. ed., 1997.

1. Keenan JA, Segars JH, Herbert CM and Maxson WS: The Prevalence of Intraperitoneal Chlamydial Antigen in Asymptomatic Infertility Patients. Infertility 9:283-287, 1986.

2. Keenan JA, Herbert CM and Wentz AC: Diagnosis and Management of Luteal Phase Deficiency Among Patients Receiving Clomiphene Citrate for Ovulation Induction. Fertility and Sterility 51:964, 1989.

3. Keenan JA, Sacco AG, Subramanian MG, Kruger M and Yurewicz EC: Endocrine Response in Rabbits Immunized with Native Versus Deglycosylated Porcine Zona Pellucida Antigens. Biology of Reproduction 44:150-156, 1991.

4. Keenan JA and Moghissi KS: Luteal Phase Support with Human Chorionic Gonadotropin Does Not Improve Fecundity Rate in Human Menopausal Gonadotropin Stimulated Cycles. Obstetrics & Gynecology 79:6, 983-987, 1992.

5. Keenan JA, Chen TT, Chadwell NL, Torry DS, and Caudle MR: Interferon Gamma (IFN-g) & Interleukin-6 (IL-6) in Peritoneal Fluid and Macrophage Conditioned Media of Women with Endometriosis. American Journal of Reproductive Immunology. 32:180-183, 1994.

6. Bukovsky A, Caudle MR, Keenan JA, Wimalasena J, Foster JS and Van Meter SE: Quantitative Evaluation of the Cell Cycle-Related Retinoblastoma Protein and Localization of Thy-1 Differentiation Protein and Macrophages during Follicular Development and Atresia, and in Human Corpora Lutea. Biology of Reproduction, 52:776-792, 1995.

7. Bukovsky A, Caudle MR, Keenan JA, Wimalasena J, Upadhyaya NB, and Van Meter SE: Expression of Cell Cycle Regulatory Proteins (pRb, p53) In The Human Female Genital Tract. Journal of Assisted Reproduction and Genetics, 12(2):123-131, 1995.

8. Keenan JA, Chen TT, Chadwell NL, Torry DS, Caudle MR: IL-1b, TNF-a , and IL-2 in Peritoneal Fluid and Macrophage Conditioned Media of Women with Endometriosis. The American Journal of Reproductive Immunology, 34(6):381-385, 1995.

9. Bukovsky A, Caudle MR, Keenan JA, Wimalasena J, Upadhyaya NB and Van Meter SE: Is Corpus Luteum Regression an Immune-Mediated Event: Localization of Immune System Components and Luteinizing Hormone Receptor in Human Corpora Lutea. Biology of Reproduction, December 1995; 53(6):1373-1384.

10. Torry DS, Holt VJ, Keenan JA, Harris GS, Caudle MR, and Torry RJ: Vascular Endothelial Cell Growth Factor (VEGF) Expression in Cycling Human Endometrium. Fertility and Sterility, In Press.

11. Bukovsky A and Keenan JA, Caudle MR, Wimalasena J and Van Meter S: Immunohistochemical Studies of the Adult Human Ovary: Possible Contribution of Immune and Epithelial Factors to Folliculogenesis. American Journal of Reproductive Immunology, 33:323-340, 1995.

12. Bukovsky A, Caudle MR, Keenan JA, Wimalasena J, Upadhyaya N and Van Meter SE: Irregular Regression of Corpora Lutea in Climacteric Women: Evidence for Age-Induced Alterations in Tissue Control System. Amer. J. Reprod. Immunol, 36:327-341;1996

13. Massey PJ, Rodriguez KM., Keenan JA, Warikoo PK, Harris GS, Chen TT, and Caudle MR: The Role of Peritoneal Fluid Factors in Endometriosis-Associated Ovarian Dysfunction: Two Granulosa Cell Models, Human Reproduction. (Submitted)

14. Torry DS, Holt VJ, Keenan JA, Harris GS, Warikoo PK, McKenzie PP, Caudle MR and Torry RJ: Expression of Vascular Endothelial Growth Factor (VEGF) in Human Endometrium. Fertility and Sterility, 66(1):72-80; 1996.

15. Bukovsky A, Caudle MR, Keenan, Wimalasena J, McKenzie PP: Vascular Pericytes and the Association of Thy-1 Differentiation Protein with the Regeneration and Terminal Differentiation of Villous Components of Mature Human Placentae. Placentae, November 25, 1997.

16. Bukovsky A, Caudle MR, Dominguez R, Ayala ME, Keenan JA, Wimalasena J: Developmental Changes of Luteinizing Hormone (LH) Receptor Expression, and Its Absence in the Ovaries of Postnatally Estrogenized Immature and Adult Female Rats. Endocrinology. (Submitted)

17. Keenan JA, Rizvi S, Caudle MR: Prognostic Factors in Fetal Loss After Early Detection of Heart Motion in Infertility Patients. Journal of Reproductive Medicine. 43 (3: 199-202, 1998.

18. Keenan JA, Boyce PKW, Massey P, Chen TT, Caudle MR, Bukovsky A: Regression of Endometrial Explants in a Rat Model of Endometriosis Treated with the Immune Modulators Loxoribine and Levamisole. Fertility and Sterility. (In Press March 1999)

19. Bukovsky A, Ayala ME, Dominguez R, Keenan JA, Wimalasena J, Caudle MR: Postnatal Androgenization Induces Premature Aging of Rat Ovaries. Biology of Reproduction. (Submitted)